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Total 72,298 individuals with Korean chip genotyped and imputed (total 8,056,211 variants) were used in our analysis. Analyses on continuous and binary phenotypes were conducted using SAIGE, adjusting for genetic relatedness, sex, age, the first 10 principal components and assessment details (cohort and year of examination). For categorical phenotypes, we used POLMM (a proportional odds logistic mixed model), adjusting for the same covariates in SAIGE.
More details are described in the paper.
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